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example, the development ofa new pharmaceutical manufacturing process selected for the formulation of awater-insoluble drug may prove to be quite risky at the time of initiation whileno proof is available that the drug will be absorbed and consistent systemicexposures will be achieved in humans. the increased bronchial secretion,the perspiration, the acceleration of the pulse and other attendantsymptoms are similarly reflex in origin from the gastric irritation anddo not indicate any direct action on the bronchi and other organs.when large doses are iniected hypodermically, emetine induces nausea,vomiting, and cheapest pharmacy for levitra purging, and blood is frequently voided in the stools, a condi-tion of collapse follows, and the animal generally dies of exhaustion in thecourse of a few hours after the onset of the symptoms. in doubtful cases the urine or thestools may be tested for lead. protoveratrine seems tocause less irritation of the sensory terminations than veratrine, and 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